Functions of longevity genes (Telomere)
Doctor's health advice
It has been found that telomeres stick to both ends of chromosomes, which are like plastic covers that bundle shoelaces. Telomere DNA becomes shorter little by little at each cell division. Then subsequently cells become unable to be divided any more, and finally die. This can be called "aging of the cell." Telomeres, are also called as if" coupon tickets for a lifetime", which are deeply associated with development of serious diseases such as cancer, arteriosclerosis, and myocardial infarction. I would like to cite an example; when cells are damaged by ultraviolet rays which sometimes trigger skin cancer, or by tobacco which may cause cancer, cell divisions become active in order to replace damaged cells with new ones. As a result, telomeres in these cells become shorter in less time. Cells become unstable once they lose telomeres, and may be connected to other chromosomes. Alcoholic hepatitis progresses to liver cirrhosis, and eventually to liver cancer in this process. Telomeres in patients with cancer or other diseases tend to be shorter. However, people whose telomeres are shorter don't necessarily suffer from cancer. Additionally, it has been clarified that our bodies also have enzyme called telomerase, however, unfortunately no reliable way to activate telomeres to lengthen telomeres have been found. Although telomere is attracting a great attention as an indicator to measure aging status in anti-aging medicine societies, further studies and researches are required to apply this mechanism in clinical practices.
We conduct researches on genes related to aging in the laboratory of our hospital. We would like to develop a technology to evaluate the biological age of patients, and to objectively measure effects of anti-aging supplements including ImunoBran.
Midori Meshitsuka M.D.
M Regenerative Clinic Director