Strengthening the immune system has never been more urgent: how ImunoBran can help.

Strengthening the immune system
18 March 2023 by
Strengthening the immune system has never been more urgent: how ImunoBran can help.
ImunoBran Luxembourg et France
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By Linda Vezzoli (Nutritional therapist)

Imunobran MGN-3 is a Japanese immunomodulator derived from rice bran. This dietary supplement was developed in the mid-1990s by Professor Ghoneum in the United States and Dr Maeda in Japan to help support immune function, particularly in patients whose immune systems have been compromised by illness and/or toxic treatments. It is a pharmacologically active natural product, sold in 49 countries, which is safe and non-toxic (1).

The rice bran extract contained in ImunoBran has been broken down by an enzyme derived from the Shiitake mushroom. The main chemical structure of ImunoBran (MGN3) is arabinoxylane. Its low molecular weight enables it to be absorbed in the small intestine and then pass into the bloodstream, where it helps to activate key immune cells such as dendritic cells (9, 10), B lymphocytes, T lymphocytes and natural killer cells (11, 12, 13).

Studies confirm its usefulness as an adjuvant for people undergoing treatment for rheumatoid arthritis (2), HIV (3), type 2 diabetes (4, 5), irritable bowel syndrome (6), asthma (7) and hepatitis (8), but research has focused mainly on boosting the immunity of people undergoing cancer treatment. The number of peer-reviewed studies on this natural compound is exceptional (59 to date), allowing doctors and practitioners to recommend it with confidence. It is well established that it increases the activity of natural killer cells (11, 12, 13), which research has shown play an important role in immune defence against cancer. A 2017 study showed that ImunoBran/MGN-3 induced a significant increase in NK activity, which could increase resistance to viral infections and cancers in the geriatric population(15). A 2012 study carried out on healthy adults also concluded that ImunoBran "may not only help to directly destroy tumour cells and viruses, but also increase immune cell activity, thereby optimising the immune system, particularly natural killer cells, which may increase the host's chances and speed of recovery". (14)​

A 2020 study showed that ImunoBran MGN-3 effectively attenuates radiation-induced changes in intestinal epithelial mitochondrial function, oxidative stress, inflammatory response, apoptosis, intestinal permeability and barrier function in mice, (16) showing a promising use of ImunoBran for the protection of our intestinal health, which is vital for immune health.

Research has also shown that, provided ImunoBran MGN-3 is regularly included in the diet, this stimulation of the immune system does not diminish over time. This lack of attenuation (or hypersensitivity) with prolonged use is extremely unusual for immunomodulatory substances and means that ImunoBran MGN-3 continues to be an effective adjunct over an extended period - important for long-term treatment plans. NK activity typically peaks 1 or 2 months after a high dose, after which it can be maintained with a lower maintenance dose. The rate at which this peak is reached depends on the dose.

In general, a dose of 500 mg to 1000 mg per day is recommended, although some practitioners initially recommend a dose of 3000 mg per day during the first month or two, and during periods of severe immunosuppression.


  1. Acute Oral Toxicity TestTest: LD50Lab: AMA Laboratories, New York, USA (Ref: WP96-BERN1/LD504881.DP). (Animal Experiment involving rats to determine any potential toxicity of MGN-3. Above material can be classified as non-toxic according to the reference. LD50 > 36.0g / kg.)
  2. Experience with Administration of Biobran in Patients with Chronic RheumatismAuthor: Kenichi Ichihashi (Ichihashi Clinic)Journal: Clinical Pharmacology and Therapy Vol. 14/No.4
  3. Anti-HIV activity in vitro of MGN-3, an activated arabinoxylan from rice branAuthor: M. GhoneumJournal: Biochemical and Biophysical Research Communications Journal 243, 25-29 (1998), Article No. RC978047. (This is a detailed write up of the abstract Ghoneum presented in July 1996 at the International Conference on AIDS in Vancouver.)
  4. Modified Rice Bran Improves Glucose Tolerance in NIDDM Adult Rats Given Streptozotocin as NeonatesAuthors: Ohara, K. Onai and H. Maeda, 2002
  5. Hyrolyzed rice bran reduces the aggravation of protein metabolism in streptozotocin-induced diabetic ratsPresenters: Kitamura N., Ohara I., (Aichi Gakusen University) and Maeda H. (Daiwa Pharmaceutical)Event: 45th Annual Meeting of the American College of Nutrition in California. Kitamura 2004
  6. Therapeutic Effects of Biobran, Modified Arabinoxylan Rice Bran, in Improving Symptoms of Diarrhea Predominant or Mixed Type Irritable Bowel Syndrome: A Pilot, Randomized Controlled StudyAuthors: Takeshi Kamiya, Michiko Shikano, Mamoru Tanaka, Keiji Ozeki, Masahide Ebi, Takahito Katano, Shingo Hamano, Hirotaka Nishiwaki, Hironobu Tsukamoto, Tsutomu Mizoshita, Yoshinori Mori, Eiji Kubota, Satoshi Tanida, Hiromi Kataoka, Noriaki Okuda, and Takashi JohJournal: Evidence-Based Complementary and Alternative Medicine / Hindawi Publishing Corporation Volume 2014, Article ID 828137, 6 pages
  7. Evaluation of the effects of asthma prevention and symptom reduction by enzymatically modified rice-bran foods in asthmatic model micePresenters: Kanbayashi H. and Endo Y., Department of Pathological Molecular Medicine, McMaster UniversityEvent: 52nd Conference of Japanese Society of Allergology, Jokohama, Japan
  8. Protective effect of low molecular fraction of MGN-3, a modified arabinoxylan from rice bran, on acute liver injury by inhibition of NF-kB and JNK/MAPK expressionPresenters: Surina Zheng, Shunsuke Sugita, Shizuka Hirai, Yukari EgashiraEvent: International Immunopharmacology 14 (2012) 764-769
  9. Biobran-augmented maturation of human monocyte-derived dendritic cellsAuthors: D. Cholujova, J. Jakugikova, J. SedlakJournal: Neoplasma 56, 2, 2009.
  10. Activation of Human Monocyte-Derived Dendritic Cells In Vitro by the Biological Response Modifier Arabinoxylan Rice Bran (MGN-3/Biobran)Authors: M. Ghoneum and S. AgrawalJournal: Journal of Immunopathology and Pharmacology, Vol.24, no.4, 941-948 (2011)
  11. Enhancement of Natural Killer Cell Activity of Aged Mice by Modified arabinoxylan rice bran (MGN3/Biobran)Authors: Ghoneum, AbediJournal: J Pharm Pharmacol 2004;56:1581-8.
  12. Evalutation of flow cytometry-based assay for natural killer cell activity in clinical settingsAuthors: Valiathan, Lewis, Melillo, Leonard, Alis, AsthanaJournal: Scandinavian Journal of Immunology 2011; 1365-3083
  13. Arabinoxylan rice bran (MGN3/Biobran) enhances natural killer cell-mediated cytotoxicity against neuroblastoma in vitro and in vivo.Authors: Perez-Martinez, Valentin, Fernandez, Hernandez-Jimenez, Lopez-Collezo, Zerbes, Schworer, Nunez, Martin, Sallis, Diaz, Handgretinger and Pfeiffer.Journal: Cytotherapy, 2015, 0:1-2.
  14. An Open-label, randomized clinical trial to assess the immunomodulatory activity of a novel oligosaccharide compound in healthy adultAuthors: K. H. Ali, A. B. Melillo, S. M. Leonard, D. Asthana, Judi M. Woolger, A. H. Wolfson, H. R. McDaniel, J. E. LewisJournal: Functional Foods in Health and Disease 2012, 2(7): 265-279
  15. Biobran/MGN-3, an arabinoxylan rice bran, enhances NK cell activity in geriatric subjects: A randomized, double-blind, placebo-controlled clinical trialAuthors: AHMED F. ELSAID, MAGDA SHAHEEN and MAMDOOH GHONEUM(edited by Chris Gutch PhD.)2017
  16. Arabinoxylan rice bran (MGN-3/Biobran) alleviates radiation-induced intestinal barrier dysfunction of mice in a mitochondrion-dependent mannerAuthors: Zhao Z, Cheng W, Qu W, Wang KJournal: Biomed Pharmacother. 2020 Apr;124:109855. doi: 10.1016/j.biopha.2020.109855. Epub 2020 Jan 24.

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