Doctor's advice: ImunoBran - One of the most studied and powerful immunomodulators known to science.

Take advantage of ImunoBran to help you achieve and maintain optimal immune function and good health!
18 March 2023 by
Doctor's advice: ImunoBran - One of the most studied and powerful immunomodulators known to science.
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John E. Lewis, Ph.D. - Associate Professor, University of Miami 

As many of you already know, the immune system is the body's first line of defence against pathogens or harmful molecules, and is involved in the inflammatory response to injury. Appropriate acute (or short-term) inflammation has been well documented as a response to tissue trauma or infection that produces characteristic symptoms, such as fever, redness, swelling and pain, and usually resolves spontaneously. More recent studies have shown that chronic inflammation is a key factor in the development of chronic degenerative diseases and accelerates the ageing process. Chronic systemic inflammation is implicated in several of the leading causes of death in the United States and the rest of the world, including cardiovascular disease and stroke, cancer, diabetes, Alzheimer's disease and other dementias, respiratory disease and nephritis. Excessive calorie consumption, high blood sugar levels, toxins and additives in the diet, processed foods and a sedentary lifestyle are just some of the causes of chronic inflammation through a faulty distress signal sent to the immune system.

At the cellular level, mitochondria become dysfunctional after exposure to external (e.g. environmental toxins, tobacco smoke) and internal (e.g. reactive oxygen species) stressors and as a result of the ageing process itself. In addition, a by-product of energy production by mitochondria is the creation of free radicals, which cause oxidative stress that can damage cellular structures and trigger a cascade of inflammatory genetic signals that ultimately lead to cell death or uncontrolled cell growth - the hallmark of cancer. It's now easy to understand why consuming foods and food supplements rich in antioxidants and other key phytochemicals can help our bodies counteract this damage and promote cell repair.

As I said, dysfunction of the immune system and its effects on the body are at the root of many health problems that are now reaching epidemic levels. It is therefore essential to support and strengthen the immune system to prevent recurrent infections, cardiovascular disease, cancer, allergies, chronic fatigue and fibromyalgia, among others. As we all know, exercise, a balanced diet, sufficient rest and stress management are extremely important for good health. Unfortunately, in today's world we are exposed to so many toxins and chemicals, from our personal products to the food we eat, as well as air and water pollution, that our immune systems are overloaded and at the same time under-reactive or out of whack. High-quality food supplements are therefore essential to help get our immune system, and our health, back on track and keep it there.

ImunoBran is one such supplement, which has consistently demonstrated powerful immunomodulatory activity in over 40 peer-reviewed studies for over 20 years. Produced from rice bran hydrolysed by shiitake mushroom enzymes, ImunoBran is 100% natural, totally safe and has no known side effects, except in the very rare case of an allergy to rice or mushrooms. As a complete herbal food supplement, ImunoBran has no interaction with pharmaceutical products and can therefore be taken independently of any current medication regime. One of the in vitro studies conducted on this supplement shows that ImunoBran improves the intracellular destruction of microbes by human phagocytic cells, which form part of our immune system's first line of defence. The results of this particular study may have implications for the treatment of infections in the elderly and immunocompromised patients. In cancer patients, a three-year study showed that ImunoBran improved the effects of interventional therapies for the treatment of hepatocellular carcinoma. Other studies have shown that ImunoBran increases the activity of natural killer cells, which are crucial for detecting and destroying tumour cells, in patients with cell lines from multiple myeloma and neuroblastoma, both fatal forms of cancer. ImunoBran also reduces the side effects of chemotherapy in breast cancer patients. What's more, the beneficial effects of ImunoBran are even greater when used in combination with other immunomodulatory and anti-inflammatory supplements, such as curcumin, as a synergistic adjunct to the treatment of other types of malignant tumours, which can lead to a delay in disease progression, while prolonging survival.

However, you don't have to be ill to benefit from daily consumption of ImunoBran. In fact, healthy adults can also benefit from its immunomodulatory effect. As numerous research and case studies have shown, this supplement optimises the activity of natural killer cells against cancerous and virus-infected cells, increases the number of B and T lymphocytes, and promotes the regulation of cytokines and interleukins, all of which have clear anti-inflammatory and antioxidant effects on the body. In our laboratory, we showed that ImunoBran demonstrated perfect, real immunomodulation in healthy adults. The subjects in our study took ImunoBran for 60 days and the cytotoxicity of their natural killer cells was assessed at baseline, 48 hours, one week, 30 days and 60 days. After peaking at one week, natural killer cell function returned to approximately baseline levels, meaning that immune system monitoring was activated, detected no discernible threat to the participants, and then deactivated. This is the very definition of immunomodulation, as opposed to immunostimulation, which would not be optimal in the long term.

After completing the study on healthy adults, we turned our attention to the studies on HIV and non-alcoholic fatty liver disease (NAFLD). As both of these diseases are chronic in nature, they are known to exhibit features of immune dysregulation that compromise health. For example, although HIV is no longer considered a fatal disease, its drugs are highly toxic and cause major metabolic disturbances. NAFLD, on the other hand, has no known conventional medical treatment; only weight loss has been shown to be effective in reducing fatty deposits in the liver. So, in each disease, immunomodulation could prove beneficial for people affected by one or other of these conditions. In the HIV study, we showed a significant improvement in the CD4/CD8 ratio (below 1.0) in response to treatment with ImunoBran, which is crucial for reducing the risk of various cancers in this population. In the NAFLD study, we found that alkaline phosphatase (an important liver enzyme) improved and that other markers of inflammation, interferon-γ and interleukin-18, also changed significantly. Thus, in both studies, we noted short-term improvements in immune function in both disease states that may provide alternative or complementary treatment considerations for these populations.

As an important adjunct to an overall approach to health, including appropriate diet and exercise, I take 1 gram a day of ImunoBran and I urge you to do the same. Even if you don't have an illness or infection, ImunoBran will keep your immune system functioning optimally and help you never to fall ill. The dosage should be adjusted accordingly on a case-by-case basis or in combination with other food supplements or disease treatment regimes. In any case, take advantage of ImunoBran to help you achieve and maintain optimal immune function and good health!

Profile

John E. Lewis, Ph.D.

Associate Professor, University of Miami

Titles:
Associate Professor of Psychiatry and Behavioral Sciences at the University of Miami Miller School of Medicine
Director of Research for the Center for Complementary and Integrative Medicine at the University of Miami Miller School of Medicine
Advisor, Diplomat, and Faculty member of the Medical Wellness Association
Education:
1990 B.S., Business Administration, University of Tennessee
1992 M.S., Exercise Physiology, University of Tennessee
1995 Ph.D., Education and Psychological Studies, University of Miami

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